ABSTRACT
Objective To compare the time and spatial distribution of hepatitis C and HIV/AIDS cases and its correlation,in China from 2012 to 2017.Methods Data on reported hepatitis C and HIV/AIDS cases was gathered from the Direct Reporting System of Infectious Diseases Information Network in China,2012 to 2017 while annually collected provincial data was based on the date of review and current address.Correlation of the data was analyzed,using both simple correlation and linear regression methods.Results The number of reported cases of hepatitis C remained stable in China,in 2012-2017,with the number of annual reported cases as 201 622,203 155,202 803,207 897,206 832 and 214 023,respectively.The number of reported cases on HIV/AIDS showed a steady growing trend,from 82 434,90 119,103 501,115 465,124 555 to 134 512.However,the numbers of hepatitis C and HIV/AIDS cases were in the same,top six provinces:Henan,Guangdong,Xinjiang,Guangxi,Hunan and Yunnan.Results from the simple correlation analysis indicated that there was a positive correlation (r＞0.5,P＜0.01) existed between the above-said two kinds of cases at the provincial level in China,in 2012-2017.Again,results from the linear regression analysis also showed that the correlation coefficient r,and year was strongly correlated (r=0.966) while rs had been linearly increasing with time.Conclusions Our data showed that there were temporal and spatial correlations existed between the reported cases of hepatitis C and HIV/AIDS at the provincial level,suggesting that relevant prevention and control programs be carried out in areas with serious epidemics.Combination of the two strategies should be encouraged,especially on prevention and treatment measures related to blood transmission.
ABSTRACT
Objective To compare the time and spatial distribution of hepatitis C and HIV/AIDS cases and its correlation,in China from 2012 to 2017.Methods Data on reported hepatitis C and HIV/AIDS cases was gathered from the Direct Reporting System of Infectious Diseases Information Network in China,2012 to 2017 while annually collected provincial data was based on the date of review and current address.Correlation of the data was analyzed,using both simple correlation and linear regression methods.Results The number of reported cases of hepatitis C remained stable in China,in 2012-2017,with the number of annual reported cases as 201 622,203 155,202 803,207 897,206 832 and 214 023,respectively.The number of reported cases on HIV/AIDS showed a steady growing trend,from 82 434,90 119,103 501,115 465,124 555 to 134 512.However,the numbers of hepatitis C and HIV/AIDS cases were in the same,top six provinces:Henan,Guangdong,Xinjiang,Guangxi,Hunan and Yunnan.Results from the simple correlation analysis indicated that there was a positive correlation (r＞0.5,P＜0.01) existed between the above-said two kinds of cases at the provincial level in China,in 2012-2017.Again,results from the linear regression analysis also showed that the correlation coefficient r,and year was strongly correlated (r=0.966) while rs had been linearly increasing with time.Conclusions Our data showed that there were temporal and spatial correlations existed between the reported cases of hepatitis C and HIV/AIDS at the provincial level,suggesting that relevant prevention and control programs be carried out in areas with serious epidemics.Combination of the two strategies should be encouraged,especially on prevention and treatment measures related to blood transmission.
ABSTRACT
@#Objective To analyze the physiologically active substances, named amino acid neurotransmitters, ATP and Ca2+ in rat spinal synaptosomes. Methods The spinal synaptosome was extracted by discontinuous Percoll density gradient centrifugation from a female Sprague-Dawley rat. The amino acid neurotransmitters were determined with high performance liquid chromatography, ATP content, Na+-K+-ATPase activity, Ca2+-Mg2+-ATPase activity and total ATPase activity with ultraviolet spectrophotometer, and Ca2+ concentration with fluorescence spectrophotometer. Results The amino acid neurotransmitters contained mainly aspartic acid, glycine, glutamic acid and r-aminobutyric acid. The concentration of ATP was about 414.7461 μmol/mg, total ATPase activity > Na+-K+-ATPase activity > Ca2+-Mg2+-ATPasese activity. The concentration of Ca2+ could be calculated from absorbancy directly. Conclusion The rat spinal synaptosome contains a variety of physiologically active substances, which can be accurately analyzed to explore their activities.
ABSTRACT
@#The neuropeptide Y receptors system is a receptor-ligand system composed of neuropeptide Y and its receptors, which is represented by two subtypes, including Y1 receptor (Y1R) and Y2 receptor (Y2R). The system is widely involved in pain modulation in mammals. These receptors are G protein-coupled receptors, participating in neuronal membrane signaling. Neuropeptide Y receptors distribute in the pain-related regions of the central nervous system, play a variety of roles in maintains neuronal activity of pain transmission, relate to the specificity of distribution. At the spinal level, Y1R plays an analgesic role, whereas Y2R is usually related to pain-promoting. The system can also take part in cerebral pain modulation at different nuclei.